Article DetailsTumors Caused by Asbestos Exposure |
| Date Added: April 19, 2010 02:04:37 PM |
| Author: Monty Wrobleski |
| Category: Health |
| Asbestos is a known carcinogen, and is appropriately regulated today. Unfortunately, that wasn’t always the case. Some estimates place the number of asbestos related deaths close to a quarter million. Consequently, a great deal of research has been done trying to better understand the relationship between exposure and the development of disease. One interesting study is called, “Malignant mesothelioma induced by asbestos and zeolite in the mouse peritonenal cavity” by Suzuki, Y. and Kohyama, N. - Environ. Res.; (United States); Journal Volume: 35:1. Here is an excerpt: “The carcinogenicity of asbestos (amosite and chrysotile) and zeolite (fibrous erionite, mordenite, and synthetic zeolite 4A) were studied in the peritoneum of 586 BALB/C male mice after a single intraperitoneal or intraabdominal wall injection. Tumors developed in 93 of 394 animals (23.6%) treated with asbestos or fibrous erionite 7 months or more after administration. All of the induced peritoneal tumors were intimately associated with marked peritoneal fibrosis, in which asbestos or erionite fibers were regularly detected. Histopathologically, 83 of 93 were consistent with malignant mesotheliomas. Other tumors consisted of 6 plasmacytomas, 1 histiocytoma, 1 liposarcoma, 1 osteosarcoma, and 1 adenocarcinoma of the pancreas. Two of the cases of mesotheliomas were associated with plasmacytoma. In many instances, the primary site of the mesotheliomas seemed to be multiple, the favorite sites being the omentum, mesentery, serosae of the gastrointestinal and genital organs, the diaphragm, the capsule of the liver and spleen, and the abdominal wall peritoneum. In addition to the 93 peritoneal tumors, 3 extraperitoneal tumors (1 fibrosarcoma and 2 rhabdomyosarcomas) were induced by amosite which was probably accidentally injected into the extraperitoneal connective tissue and the striated muscle tissue of the abdominal wall, respectively. These three tumors were also intimately associated with focal fibrosis in which amosite fibers were detected. Among the three different types of zeolite, only fibrous erionite showed striking carcinogenicity and marked fibrogenicity. The erionite-induced mesotheliomas were similar to those induced by asbestos in exhibiting long latency, in gross appearance, in histology, and in close association with fibrosis. Another interesting article is called, “Participation of Nitric Oxide and Iron in the Oxidation of DNA in Asbestos-Treated Human Lung Epithelial Cells” by Chien-Chung Chao, Sun-Hee Park and Ann E. Aust - Department of Chemistry and Biochemistry, Utah State University, Logan, Utah, 84322-0300 - Archives of Biochemistry and Biophysics - Volume 326, Issue 1, 1 February 1996, Pages 152-157 Here is an excerpt: “Abstract - Treatment of human lung epithelial (A549) cells with crocidolite resulted in the formation of 8-hydroxy-2'-deoxyguanosine (8-OHdG) in the DNA, synthesis of mRNA for the inducible form of nitric oxide synthase (NOS), and increased intracellular nitrite[formula]a stable oxidation product of NO. Iron, associated with crocidolite, was involved in both[formula]and 8-OHdG formation. Addition of the NOS inhibitor, aminoguanidine (AG), reduced intracellular[formula]and prevented formation of 8-OHdG in crocidolite-treated cells, suggesting that NO was required in 8-OHdG formation. Addition of an NO-generating compound, diethyltriamine/NO, with AG and crocidolite resulted in recovery of 8-OHdG, further supporting a role for NO in oxidation of deoxyguanosine.” If you found any of these excerpts interesting, please read the studies in their entirety. We all owe a debt of gratitude to the people examining these important issues. Monty Wrobleski is the author of this article on Asbestos Exposure. Find more information about Navy Asbestos Claims here. |
